import_omnipath_intercell | R Documentation |
Imports the OmniPath intercellular communication role annotation database from https://omnipathdb.org/intercell. It provides information on the roles in inter-cellular signaling. E.g. if a protein is a ligand, a receptor, an extracellular matrix (ECM) component, etc.
import_omnipath_intercell(
organism = "human",
categories = NULL,
resources = NULL,
parent = NULL,
scope = NULL,
aspect = NULL,
source = NULL,
transmitter = NULL,
receiver = NULL,
secreted = NULL,
plasma_membrane_peripheral = NULL,
plasma_membrane_transmembrane = NULL,
proteins = NULL,
topology = NULL,
causality = NULL,
consensus_percentile = NULL,
loc_consensus_percentile = NULL,
genesymbol_resource = NULL,
...
)
organism |
Character or integer: Name or NCBI Taxonomy ID of one or organisms. The web service currently provides intercell annotations only for human. For other organisms, the data will be translated by orthologous gene pairs from human. |
categories |
vector containing the categories to be retrieved.
All the genes belonging to those categories will be returned. For
further information about the categories see
|
resources |
limit the query to certain resources; see the available
resources by |
parent |
vector containing the parent classes to be retrieved.
All the genes belonging to those classes will be returned. For
furter information about the main classes see
|
scope |
either 'specific' or 'generic' |
aspect |
either 'locational' or 'functional' |
source |
either 'resource_specific' or 'composite' |
transmitter |
logical, include only transmitters i.e. proteins delivering signal from a cell to its environment. |
receiver |
logical, include only receivers i.e. proteins delivering signal to the cell from its environment. |
secreted |
logical, include only secreted proteins |
plasma_membrane_peripheral |
logical, include only plasma membrane peripheral membrane proteins. |
plasma_membrane_transmembrane |
logical, include only plasma membrane transmembrane proteins. |
proteins |
limit the query to certain proteins |
topology |
topology categories: one or more of 'secreted' (sec), 'plasma_membrane_peripheral' (pmp), 'plasma_membrane_transmembrane' (pmtm) (both short or long notation can be used). |
causality |
'transmitter' (trans), 'receiver' (rec) or 'both' (both short or long notation can be used). |
consensus_percentile |
Numeric: a percentile cut off for the
consensus score of generic categories. The consensus score is the
number of resources supporting the classification of an entity into a
category based on combined information of many resources. Here you can
apply a cut-off, keeping only the annotations supported by a higher
number of resources than a certain percentile of each category. If
|
loc_consensus_percentile |
Numeric: similar to
|
genesymbol_resource |
Character: either "uniprot" or "ensembl". The former leaves intact the gene symbols returned by the web service, originally set from UniProt. The latter updates the gene symbols from Ensembl, which uses a slightly different gene symbol standard. In this case a few records will be duplicated, where Ensembl provides ambiguous translation. |
... |
Additional optional arguments, ignored. |
A dataframe cotaining information about roles in intercellular signaling.
get_intercell_categories
get_intercell_generic_categories
import_intercell_network
intercell_consensus_filter
intercell <- import_omnipath_intercell(categories = 'ecm')
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