Description Usage Arguments Value Author(s) References Examples
Compute a sparse, spatially coherent regression from a set of input images (with mask) to an outcome variable.
1 2 | sparseRegression(inmatrix, demog, outcome, mask=NA, sparseness=0.05, nvecs=50,
its=5, cthresh=250, statdir=NA, z=0, smooth=0)
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inmatrix |
Input data matrix, with dimension number of subjects by number of voxels. |
demog |
Input demographics data frame. Contains outcome variable to regress against. |
outcome |
Name of column in |
mask |
Mask for reconstructing |
sparseness |
Level of sparsity desired. |
nvecs |
Number of eigenvectors to return. |
its |
Number of cross-validation folds to run. |
cthresh |
Cluster threshold. |
statdir |
Where to put results. If not provided, a temp directory is created. |
z |
Row (subject-wise) sparseness. |
smooth |
Amount of smoothing. |
A list of values:
eigenanatomyimages |
Coefficient vector images. |
umatrix |
Projections of input images on the sparse regression vectors. Can be used for, e.g., subsequent classification/predictions. |
projections |
Predicted values of outcome variable. |
Kandel BM, Avants BB.
Kandel B.M., D. Wolk, J. Gee, and B. Avants. Predicting Cognitive Data from Medical Images Using Sparse Linear Regression. Information Processing in Medical Imaging, 2013.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 | require(ANTsR)
nsubj <- 1000
prop.train <- 1/2
subj.train <- sample(1:nsubj, prop.train*nsubj, replace=F)
input <- t(replicate(nsubj, rnorm(125)))
outcome <- seq(1, 5, length.out=nsubj)
demog <- data.frame(outcome=outcome)
input[, 40:60] <- 30 + outcome + rnorm(length(input[, 40:60]), sd=2)
input.train <- input[subj.train, ]
input.test <- input[-subj.train, ]
demog.train <- data.frame(outcome=demog[subj.train, ])
demog.test <- data.frame(outcome=demog[-subj.train, ])
mymask <- as.antsImage(array(rep(1, 125), dim=c(5,5,5)))
myregression <- sparseRegression(input.train, demog.train, "outcome", mymask,
sparseness=0.05, nvecs=5, its=3, cthresh=250)
# visualization of results
sample <- rep(0, 125)
sample[40:60] <-1
signal.img <- as.antsImage(array(rep(0,125), dim=c(5, 5, 5)))
signal.img[signal.img >= 0 ] <- sample
plotANTsImage( signal.img, axis=2, slices="1x5x1") # actual source of signal
# compare against first learned regression vector
myimgs <- list()
for( i in 1:5){
myarray <- as.array(myregression$eigenanatomyimages[[ i ]])
myarray <- myarray / max(abs(myarray)) # normalize for visualization
myimgs[[ i ]] <- antsImageClone(myregression$eigenanatomyimages[[ i ]])
myimgs[[ i ]][mymask > 0] <- myarray
}
plotANTsImage(myimgs[[1]], axis=2, slices="1x5x1")
# use learned eigenvectors for prediction
result <- regressProjections(input.train, input.test, demog.train,
demog.test, myregression$eigenanatomyimages, mymask, "outcome")
plot(result$outcome.comparison$real, result$outcome.comparison$predicted)
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