Description Usage Arguments Details Value Author(s) Examples

View source: R/aggregatePvals.R

This function takes as input a matrix of p-values for example obtained from a GSEA on multiple phenotypes, with a row for each gene set and a column for each phenotype and aggregates the p-values by row (i.e. one aggregated p-value for each gene set) according to Fisher or Stouffer's methods.

1 2 | ```
aggregatePvals(pvalMatrix, method="fishers", pAdjustMethod="BH",
order=TRUE)
``` |

`pvalMatrix` |
a numeric matrix of p-values, with rows named according to the gene set (rows correspond to gene sets, and columns to multiple p-values to be aggregated for that gene set) |

`method` |
a single character value of "stouffers" or "fishers" |

`pAdjustMethod` |
a single character value specifying the p-value adjustment method to be used (see 'p.adjust' for details) |

`order` |
a single logical value: TRUE or FALSE. If it is TRUE, the results table will be ordered according to the aggregated p-values. |

The Fisher method combines the p-values into an aggregated chi-squared statistic equal to -2*sum(log(Pk)) were we have k=1,..,K pvalues independently distributed as uniform on the unit interval under the null hypothesis. The resulting p-values are calculated by comparing this chi-squared statistic to a chi-squared distribution with 2K degrees of freedom. The Stouffer method computes a z-statistics assuming that the sum of the quantiles (from a standard normal distribution) corresponding to the p-values are distributed as N(0,K).

a matrix with a row for each gene set and two columns: "Aggregated.p.value" and "Adjusted.aggregated.p.value"

Jack Rose and Camille Terfve

1 2 3 4 5 6 7 |

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