Description Usage Format Source Examples
An object of class LowMACA of the alignment and mapping of the homeobox domain. It is the example used in the vignette.
1 | data("lmObj")
|
An object of class LowMACA
Created by LowMACA package
1 2 3 |
Checking if clustalo is in the PATH...
Checking perl installation...
Checking perl modules XML::Simple and LWP...
sh: 1: /usr/bin/perl: Permission denied
sh: 1: /usr/bin/perl: Permission denied
Warning messages:
1: In .ClustalChecks(ClustalCommand = "clustalo") :
Clustal Omega is not in the PATH:
You can either change clustalo command using lmParams function or use the web service. See ?setup
2: In system(paste(perl, "-MXML::Simple -e 1"), intern = TRUE) :
running command '/usr/bin/perl -MXML::Simple -e 1' had status 126
3: In .PerlModuleChecks(stop = FALSE, perl = "perl") :
XML::Simple module for perl is not installed.
If you don't want to install a local clustal omega and use the web service, XML::Simple is required
4: In system(paste(perl, "-MLWP -e 1"), intern = TRUE) :
running command '/usr/bin/perl -MLWP -e 1' had status 126
5: In .PerlModuleChecks(stop = FALSE, perl = "perl") :
LWP module for perl is not installed.
If you don't want to install a local clustal omega and use the web service, LWP is required
Formal class 'LowMACA' [package "LowMACA"] with 4 slots
..@ arguments:List of 6
.. ..$ genes : NULL
.. ..$ pfam : chr "PF00046"
.. ..$ input :'data.frame': 28 obs. of 7 variables:
.. .. ..$ Gene_Symbol : Factor w/ 27 levels "ADNP","ALX1",..: 4 13 13 12 8 5 6 19 20 23 ...
.. .. ..$ Pfam_ID : Factor w/ 1 level "PF00046": 1 1 1 1 1 1 1 1 1 1 ...
.. .. ..$ Entrez : Factor w/ 27 levels "1046","1406",..: 25 26 26 27 15 1 2 7 8 11 ...
.. .. ..$ Envelope_Start: chr [1:28] "79" "16" "102" "34" ...
.. .. ..$ Envelope_End : chr [1:28] "135" "70" "156" "90" ...
.. .. ..$ UNIPROT : Factor w/ 27 levels "ADNP_HUMAN","ALX1_HUMAN",..: 4 13 13 12 8 5 6 19 20 23 ...
.. .. ..$ AMINO_SEQ : chr [1:28] "HKERTSFTHQQYEELEALFSQTMFPDRNLQEKLALRLDLPESTVKVWFRNRRFKLKK" "RRCRTKFTEEQLKILINTFNQKPYPGYATKQKLALEINTEESRIQIWFQNRRARH" "RRCRTTYSASQLHTLIKAFMKNPYPGIDSREELAKEIGVPESRVQIWFQNRRSRL" "RRNRTTFTLQQLEALEAVFAQTHYPDVFTREELAMKINLTEARVQVWFQNRRAKWRK" ...
.. ..$ mode : chr "pfam"
.. ..$ params :List of 7
.. .. ..$ mutation_type : chr "missense"
.. .. ..$ tumor_type : chr [1:7] "skcm" "stad" "ucec" "luad" ...
.. .. ..$ min_mutation_number: num 0
.. .. ..$ density_bw : num 0
.. .. ..$ clustal_cmd : chr "clustalo"
.. .. ..$ use_hmm : logi FALSE
.. .. ..$ datum : logi FALSE
.. ..$ parallelize:List of 2
.. .. ..$ getMutations : logi FALSE
.. .. ..$ makeAlignment: logi TRUE
..@ alignment:List of 4
.. ..$ ALIGNMENT:'data.frame': 1708 obs. of 8 variables:
.. .. ..$ domainID : Factor w/ 28 levels "ARGFX|PF00046|503582|79;135",..: 1 1 1 1 1 1 1 1 1 1 ...
.. .. ..$ Gene_Symbol : Factor w/ 27 levels "ADNP","ALX1",..: 4 4 4 4 4 4 4 4 4 4 ...
.. .. ..$ Pfam : Factor w/ 1 level "PF00046": 1 1 1 1 1 1 1 1 1 1 ...
.. .. ..$ Entrez : Factor w/ 27 levels "1046","127343",..: 21 21 21 21 21 21 21 21 21 21 ...
.. .. ..$ Envelope_Start: num [1:1708] 79 79 79 79 79 79 79 79 79 79 ...
.. .. ..$ Envelope_End : num [1:1708] 135 135 135 135 135 135 135 135 135 135 ...
.. .. ..$ Align : int [1:1708] 1 2 3 4 5 6 7 8 9 10 ...
.. .. ..$ Ref : num [1:1708] 79 80 81 82 83 84 85 86 87 88 ...
.. ..$ SCORE :List of 2
.. .. ..$ DIST_MAT : num [1:28, 1:28] NA 36.4 34.5 50.9 26.3 ...
.. .. .. ..- attr(*, "dimnames")=List of 2
.. .. .. .. ..$ : chr [1:28] "ARGFX|PF00046|503582|79;135" "DUXA|PF00046|503835|16;70" "DUXA|PF00046|503835|102;156" "DRGX|PF00046|644168|34;90" ...
.. .. .. .. ..$ : chr [1:28] "ARGFX|PF00046|503582|79;135" "DUXA|PF00046|503835|16;70" "DUXA|PF00046|503835|102;156" "DRGX|PF00046|644168|34;90" ...
.. .. ..$ SUMMARY_SCORE:'data.frame': 28 obs. of 4 variables:
.. .. .. ..$ MEAN_SIMILARITY : num [1:28] 39.5 37.6 40.1 47.6 27.4 ...
.. .. .. ..$ MEDIAN_SIMILARITY: num [1:28] 38.6 36.4 40 43.9 26.3 ...
.. .. .. ..$ MAX_SIMILARITY : num [1:28] 54.4 54.5 54.5 78.9 80.7 ...
.. .. .. ..$ MIN_SIMILARITY : num [1:28] 21.1 18.2 23.6 21.1 17.5 ...
.. ..$ CLUSTAL :Formal class 'AAMultipleAlignment' [package "Biostrings"] with 3 slots
.. .. .. ..@ unmasked:Formal class 'AAStringSet' [package "Biostrings"] with 5 slots
.. .. .. .. .. ..@ pool :Formal class 'SharedRaw_Pool' [package "XVector"] with 2 slots
.. .. .. .. .. .. .. ..@ xp_list :List of 1
.. .. .. .. .. .. .. .. ..$ :<externalptr>
.. .. .. .. .. .. .. ..@ .link_to_cached_object_list:List of 1
.. .. .. .. .. .. .. .. ..$ :<environment: 0x559f23cfd7d8>
.. .. .. .. .. ..@ ranges :Formal class 'GroupedIRanges' [package "XVector"] with 7 slots
.. .. .. .. .. .. .. ..@ group : int [1:28] 1 1 1 1 1 1 1 1 1 1 ...
.. .. .. .. .. .. .. ..@ start : int [1:28] 1 62 123 184 245 306 367 428 489 550 ...
.. .. .. .. .. .. .. ..@ width : int [1:28] 61 61 61 61 61 61 61 61 61 61 ...
.. .. .. .. .. .. .. ..@ NAMES : chr [1:28] "ARGFX|PF00046|503582|79;135" "DUXA|PF00046|503835|16;70" "DUXA|PF00046|503835|102;156" "DRGX|PF00046|644168|34;90" ...
.. .. .. .. .. .. .. ..@ elementType : chr "integer"
.. .. .. .. .. .. .. ..@ elementMetadata: NULL
.. .. .. .. .. .. .. ..@ metadata : list()
.. .. .. .. .. ..@ elementType : chr "AAString"
.. .. .. .. .. ..@ elementMetadata: NULL
.. .. .. .. .. ..@ metadata : list()
.. .. .. ..@ rowmask :Formal class 'NormalIRanges' [package "IRanges"] with 6 slots
.. .. .. .. .. ..@ start : int(0)
.. .. .. .. .. ..@ width : int(0)
.. .. .. .. .. ..@ NAMES : NULL
.. .. .. .. .. ..@ elementType : chr "integer"
.. .. .. .. .. ..@ elementMetadata: NULL
.. .. .. .. .. ..@ metadata : list()
.. .. .. ..@ colmask :Formal class 'NormalIRanges' [package "IRanges"] with 6 slots
.. .. .. .. .. ..@ start : int(0)
.. .. .. .. .. ..@ width : int(0)
.. .. .. .. .. ..@ NAMES : NULL
.. .. .. .. .. ..@ elementType : chr "integer"
.. .. .. .. .. ..@ elementMetadata: NULL
.. .. .. .. .. ..@ metadata : list()
.. ..$ df :'data.frame': 61 obs. of 2 variables:
.. .. ..$ consensus : Factor w/ 18 levels "A","D","E","F",..: 13 13 1 13 15 1 4 15 14 3 ...
.. .. ..$ conservation: num [1:61] 0.326 0.472 0.156 0.883 0.652 ...
..@ mutations:List of 3
.. ..$ data :'data.frame': 1389 obs. of 8 variables:
.. .. ..$ Entrez : int [1:1389] 3199 3213 91464 23316 127343 3232 23316 644168 139324 3199 ...
.. .. ..$ Gene_Symbol : chr [1:1389] "HOXA2" "HOXB3" "ISX" "CUX2" ...
.. .. ..$ Amino_Acid_Letter : chr [1:1389] "L" "S" "P" "R" ...
.. .. ..$ Amino_Acid_Position: num [1:1389] 298 123 186 874 165 ...
.. .. ..$ Amino_Acid_Change : chr [1:1389] "L298M" "S123F" "P186A" "R874C" ...
.. .. ..$ Mutation_Type : chr [1:1389] "Missense_Mutation" "Missense_Mutation" "Missense_Mutation" "Missense_Mutation" ...
.. .. ..$ Sample : chr [1:1389] "SA236" "SA212" "SA229" "BR-M-166" ...
.. .. ..$ Tumor_Type : chr [1:1389] "brca" "brca" "brca" "brca" ...
.. ..$ freq :'data.frame': 7 obs. of 29 variables:
.. .. ..$ StudyID : Factor w/ 7 levels "brca","coadread",..: 1 2 3 4 5 6 7
.. .. ..$ Total_Sequenced_Samples: int [1:7] 1262 296 513 178 559 438 248
.. .. ..$ ADNP : int [1:7] 11 11 6 2 10 11 11
.. .. ..$ ALX1 : int [1:7] 2 4 10 6 3 7 8
.. .. ..$ ALX4 : int [1:7] 2 4 10 2 6 10 6
.. .. ..$ ARGFX : int [1:7] 3 5 9 0 19 2 2
.. .. ..$ CDX4 : int [1:7] 2 0 11 3 24 7 9
.. .. ..$ CRX : int [1:7] 3 4 9 3 13 9 4
.. .. ..$ CUX1 : int [1:7] 3 11 21 8 32 21 21
.. .. ..$ CUX2 : int [1:7] 7 9 19 3 59 21 7
.. .. ..$ DBX2 : int [1:7] 3 3 12 0 22 4 5
.. .. ..$ DLX5 : int [1:7] 3 3 12 4 8 7 1
.. .. ..$ DMBX1 : int [1:7] 2 3 5 2 23 3 7
.. .. ..$ DRGX : int [1:7] 5 5 4 2 16 2 3
.. .. ..$ DUXA : int [1:7] 2 2 8 6 12 3 5
.. .. ..$ ESX1 : int [1:7] 2 9 7 2 13 7 3
.. .. ..$ EVX2 : int [1:7] 0 2 6 2 14 12 7
.. .. ..$ HDX : int [1:7] 11 12 18 6 10 8 19
.. .. ..$ HLX : int [1:7] 3 10 7 4 7 6 8
.. .. ..$ HOXA1 : int [1:7] 3 4 11 3 14 7 9
.. .. ..$ HOXA2 : int [1:7] 5 2 14 1 7 2 5
.. .. ..$ HOXA3 : int [1:7] 1 5 11 4 18 8 3
.. .. ..$ HOXA5 : int [1:7] 3 4 19 0 9 3 1
.. .. ..$ HOXB1 : int [1:7] 0 0 14 4 14 6 2
.. .. ..$ HOXB3 : int [1:7] 4 2 14 3 10 4 2
.. .. ..$ HOXD3 : int [1:7] 2 3 8 3 9 7 6
.. .. ..$ ISL1 : int [1:7] 4 11 9 2 10 4 4
.. .. ..$ ISX : int [1:7] 3 2 5 5 27 2 5
.. .. ..$ LHX8 : int [1:7] 2 5 15 6 12 9 7
.. ..$ aligned: num [1:28, 1:61] 0 0 1 0 0 1 0 0 0 1 ...
.. .. ..- attr(*, "dimnames")=List of 2
.. .. .. ..$ : chr [1:28] "ARGFX|PF00046|503582|79;135" "DUXA|PF00046|503835|16;70" "DUXA|PF00046|503835|102;156" "DRGX|PF00046|644168|34;90" ...
.. .. .. ..$ : NULL
..@ entropy : list()
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