Gene set analysis methods exist to combine SNP-level association p-values into gene sets, calculating a single association p-value for each gene set. This package implements two such methods that require only the calculated SNP p-values, the gene set(s) of interest, and a correlation matrix (if desired). One method (GLOSSI) requires independent SNPs and the other (VEGAS) can take into account correlation (LD) among the SNPs. Built-in plotting functions are available to help users visualize results.
|Author||Caitlin McHugh, Jessica Larson, and Jason Hackney|
|Bioconductor views||GeneSetEnrichment Genetics GenomicVariation Pathways StatisticalMethod|
|Maintainer||Caitlin McHugh <[email protected]>|
|Package repository||View on Bioconductor|
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