tamr13: Function to compute the risk scores of the tamoxifen...

In genefu: Computation of Gene Expression-Based Signatures in Breast Cancer

Description

This function computes signature scores from gene expression values following the algorithm used for the Tamoxifen Resistance signature (TAMR13).

Usage

tamr13(data, annot, do.mapping = FALSE, mapping, verbose = FALSE)

Arguments

data	Matrix of gene expressions with samples in rows and probes in columns, dimnames being properly defined.
annot	Matrix of annotations with at least one column named "EntrezGene.ID", dimnames being properly defined.
do.mapping	TRUE if the mapping through Entrez Gene ids must be performed (in case of ambiguities, the most variant probe is kept for each gene), FALSE otherwise.
mapping	Matrix with columns "EntrezGene.ID" and "probe" used to force the mapping such that the probes are not selected based on their variance.
verbose	TRUE to print informative messages, FALSE otherwise.

Value

score	Continuous signature scores
risk	Binary risk classification, 1 being high risk and 0 being low risk (not implemented, the function will return NA values).

Author(s)

Benjamin Haibe-Kains

References

Loi S, Haibe-Kains B, Desmedt C, Wirapati P, Lallemand F, Tutt AM, Gillet C, Ellis P, Ryder K, Reid JF, Daidone MG, Pierotti MA, Berns EMJJ, Jansen MPHM, Foekens JA, Delorenzi M, Bontempi G, Piccart MJ and Sotiriou C (2008) "Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen", BMC Genomics, 9(1):239

See Also

gene76

Examples

## load TAMR13 signature
data(sig.tamr13)
## load VDX dataset
data(vdxs)
## compute relapse score
tamr13.vdxs <- tamr13(data=data.vdxs, annot=annot.vdxs, do.mapping=FALSE)
summary(tamr13.vdxs$score)

genefu documentation built on Jan. 28, 2021, 2:01 a.m.