splatPopEstimate: Estimate population/eQTL simulation parameters
In splatter: Simple Simulation of Single-cell RNA Sequencing Data

Description Usage Arguments Value See Also Examples

Estimate simulation parameters for the eQTL population simulation from real data. See the individual estimation functions for more details on how this is done.

splatPopEstimate(
  counts = NULL,
  means = NULL,
  eqtl = NULL,
  params = newSplatPopParams()
)

`counts`	either a counts matrix or a SingleCellExperiment object containing count data to estimate parameters from.
`means`	Matrix of real gene means across a population, where each row is a gene and each column is an individual in the population.
`eqtl`	data.frame with all or top eQTL pairs from a real eQTL analysis. Must include columns: 'gene_id', 'pval_nominal', and 'slope'.
`params`	SplatPopParams object containing parameters for the simulation of the mean expression levels for the population. See `SplatPopParams` for details.

SplatPopParams object containing the estimated parameters.

splatPopEstimateEffectSize, splatPopEstimateMeanCV

if (requireNamespace("VariantAnnotation", quietly = TRUE) &&
    requireNamespace("preprocessCore", quietly = TRUE)) {
    # Load example data
    library(scater)

    sce <- mockSCE()
    params <- splatPopEstimate(sce)
}