cubeECHACR: Inheritance Cube: ECHACR

In MGDrivE: Mosquito Gene Drive Explorer

Description

This function creates an ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.

• W: Wild-type

• H: Homing allele

• E: Eraser allele

• R: No-cost resistance allele

• B: Detrimental resistance allele

• cHW: Rate of homing from H, W -> H transition

• cEH: Rate of homing from E, H -> E transition

• cEW: Rate of homing from E, W -> E transition

Usage

cubeECHACR(
  cHW = 1,
  cEW = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  ceEW = 0,
  crEW = 0,
  ceEH = 0,
  crEH = 0,
  d1 = 0,
  d2 = 0,
  d3 = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHW	Cutting efficiency of drive allele at locus 1
cEW	Cutting efficiency of ECHACR element into W
cEH	Cutting efficiency of ECHACR element into H
chHW	Homing efficiency of drive allele at locus 1
crHW	Resistance allele efficiency of drive allele at locus 1
ceEW	Homing efficiency of ECHACR element into W
crEW	Resistance allele efficiency of ECHACR element into W
ceEH	Homing efficiency of ECHACR element into H
crEH	Resistance allele efficiency of ECHACR element into H
d1	Background mutation rate from W into R allele
d2	Background mutation rate from H into R allele
d3	Background mutation rate from E into R allele
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Details

This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives publication.

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Oct. 23, 2020, 7:28 p.m.