cubeMEDEA: Inheritance Cube: MEDEA (Maternal Effect Dominant Embryonic...

In MGDrivE: Mosquito Gene Drive Explorer

Description

This function creates an inheritance cube to model a MEDEA drive system. This system was first discovered in flour beetles. It biases inheritance by expressing a maternal toxin such that offspring die unless they express a zygotic antidote.
This drive has 3 alleles at 1 locus:

• W: Wild-type allele

• M: MEDEA allele

• R: Resistance allele

Usage

cubeMEDEA(
  rM = 0,
  rW = 0,
  Teff = 1,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

rM	Breakdown of MEDEA allele, no homing/toxin/antidote, M -> R conversion
rW	De novo resistance generation, W -> R conversion
Teff	Efficacy of the toxin
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Oct. 23, 2020, 7:28 p.m.