cubeHomingDriveSM: Inheritance Cube: CRISPR-SM (Clustered Regularly Interspaced...

In MGDrivE: Mosquito Gene Drive Explorer

Inheritance Cube: CRISPR-SM (Clustered Regularly Interspaced Short Palindromic Repeats) with Small-Molecule Induction and 1 Resistance Allele and Maternal Deposition

Description

This is a sex-specific version of CRISPR with small-molecule induced homing. It assumes that the construct is on an autosome and there can be different male/female homing rates. It also has maternal deposition, i.e., when the male provides a W allele to a female with a H allele, some portion are cut during oogenesis. Additionally, this cube is designed for small-molecule induction, i.e., with the SM branch of MGDrivE. It allows the homing (H) allele to be turned off into an O allele, which inherits stably, and so that all offspring of H individuals are O until turned on with the spray. If the maternal deposition parameters are zero (d* parameters), this is a normal CRISPR drive.

Usage

cubeHomingDriveSM(
  cM = 1,
  cF = 1,
  dF = 0,
  chM = 0,
  chF = 0,
  dhF = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cM	Male homing rate
cF	Female homing rate
dF	Female deposition homing rate
chM	Male correct homing rate
chF	Female correct homing rate
dhF	Female correct deposition rate
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Sept. 9, 2025, 5:42 p.m.