cubeImmunizingReversalX: Inheritance Cube: Immunizing Reversal

In MGDrivE: Mosquito Gene Drive Explorer

Inheritance Cube: Immunizing Reversal

Description

This function creates an Immunizing Reversal construct, it has 5 alleles at 1 locus

• W: Wild-type

• H: Homing allele

• E: Eraser allele

• R: No-cost resistance allele

• B: Detrimental resistance allele

Usage

cubeImmunizingReversalX(
  cHW = 1,
  cEW = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  ceEW = 0,
  crEW = 0,
  ceEH = 0,
  crEH = 0,
  dHW = 0,
  dEW = 0,
  dEH = 0,
  dhHW = 0,
  drHW = 0,
  deEW = 0,
  drEW = 0,
  deEH = 0,
  drEH = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHW	Cutting efficiency of H into W
cEW	Cutting efficiency of E into W
cEH	Cutting efficiency of E into H
chHW	Homing efficiency of H at W
crHW	Resistance generation efficiency of H at W
ceEW	Homing efficiency of E at W
crEW	Resistance generation efficiency of E at W
ceEH	Homing efficiency of E at H
crEH	Resistance efficiency of E at H
dHW	H deposition efficiency against W
dEW	E deposition efficiency against W
dEH	E deposition efficiency against H
dhHW	H deposition homing efficiency against W
drHW	H deposition resistance efficiency against W
deEW	E deposition homing efficiency against W
drEW	E deposition resistance efficiency against W
deEH	E deposition homing efficiency against H
drEH	E deposition resistance efficiency against H
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Details

This is the general form for an immunizing reversal drive. If the c_EW and d_EW, parameters are all 0, then this simplifies to a basic reversal drive. This drive represents an X-linked IR drive.

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Sept. 9, 2025, 5:42 p.m.