cubeASmidler: Inheritance Cube: Split-Drive for Andrea Smidler

In MGDrivE: Mosquito Gene Drive Explorer

Inheritance Cube: Split-Drive for Andrea Smidler

Description

This is a modified split-drive construct for split-suppression drives. This is an autosomal, 2-locus drive. The first locus contains the Cas9 allele and the second locus has the gRNA construct. Cas9 efficacy in each sex is dependent upon parent of inheritance. This construct has 3 alleles at the first locus and 4 alleles at the second.

• Locus 1

  • W: Wild-type

  • P: Paternal Cas9

  • M: Maternal Cas9

• Locus 2

  • W: Wild-type

  • G: gRNAs

  • R: Resistant 1

  • B: Resistant 2

Usage

cubeASmidler(
  cMM = 0,
  chMM = 0,
  crMM = 0,
  cPM = 0,
  chPM = 0,
  crPM = 0,
  cMF = 0,
  chMF = 0,
  crMF = 0,
  cPF = 0,
  chPF = 0,
  crPF = 0,
  crF = 0.5,
  crM = 0.5,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cMM	Cutting efficacy of maternally-inherited Cas9 in males
chMM	Homing efficacy of maternally-inherited Cas9 in males
crMM	Resistance rate of maternally-inherited Cas9 in males
cPM	Cutting efficacy of paternally-inherited Cas9 in males
chPM	Homing efficacy of paternally-inherited Cas9 in males
crPM	Resistance rate of paternally-inherited Cas9 in males
cMF	Cutting efficacy of maternally-inherited Cas9 in females
chMF	Homing efficacy of maternally-inherited Cas9 in females
crMF	Resistance rate of maternally-inherited Cas9 in females
cPF	Cutting efficacy of paternally-inherited Cas9 in females
chPF	Homing efficacy of paternally-inherited Cas9 in females
crPF	Resistance rate of paternally-inherited Cas9 in females
crF	Female crossover rate, 0 is completely linked, 0.5 is unlinked, 1.0 is complete divergence
crM	Male crossover rate, 0 is completely linked, 0.5 is unlinked, 1.0 is complete divergence
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Sept. 9, 2025, 5:42 p.m.