cubeImmunizingReversalMF: Inheritance Cube: Immunizing Reversal/Basic Reversal

In MGDrivE: Mosquito Gene Drive Explorer

Inheritance Cube: Immunizing Reversal/Basic Reversal

Description

This function creates an Immunizing Reversal construct, it has 5 alleles at 1 locus

• W: Wild-type

• H: Homing allele

• E: Eraser allele

• R: No-cost resistance allele

• B: Detrimental resistance allele

Usage

cubeImmunizingReversalMF(
  cHWM = 1,
  cHWF = 1,
  cEWM = 1,
  cEWF = 1,
  cEHM = 1,
  cEHF = 1,
  chHWM = 0,
  chHWF = 0,
  crHWM = 0,
  crHWF = 0,
  ceEWM = 0,
  ceEWF = 0,
  crEWM = 0,
  crEWF = 0,
  ceEHM = 0,
  ceEHF = 0,
  crEHM = 0,
  crEHF = 0,
  dHW = 0,
  dEW = 0,
  dEH = 0,
  dhHW = 0,
  drHW = 0,
  deEW = 0,
  drEW = 0,
  deEH = 0,
  drEH = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHWM	Cutting efficiency of H into W in males
cHWF	Cutting efficiency of H into W in females
cEWM	Cutting efficiency of E into W in males
cEWF	Cutting efficiency of E into W in females
cEHM	Cutting efficiency of E into H in males
cEHF	Cutting efficiency of E into H in females
chHWM	Homing efficiency of H into W in males
chHWF	Homing efficiency of H into W in females
crHWM	Resistance efficiency of H into W in males
crHWF	Resistance efficiency of H into W in females
ceEWM	Homing efficiency of E into W in males
ceEWF	Homing efficiency of E into W in females
crEWM	Resistance efficiency of E into W in males
crEWF	Resistance efficiency of E into W in females
ceEHM	Homing efficiency of E into H in males
ceEHF	Homing efficiency of E into H in females
crEHM	Resistance efficiency of E into H in males
crEHF	Resistance efficiency of E into H in females
dHW	Deposition cutting efficiency of H into W
dEW	Deposition cutting efficiency of E in to W
dEH	Deposition cutting efficiency of E into H
dhHW	Deposition homing efficiency of H into W
drHW	Deposition resistance efficiency of H into W
deEW	Deposition homing efficiency of E into W
drEW	Deposition resistance efficiency of E into W
deEH	Deposition homing efficiency of E into H
drEH	Deposition resistance efficiency of E into H
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Details

This is the general form for an immunizing reversal drive. If the EW terms are 0, then this simplifies to a basic reversal drive.This drive handles different male and female homing rates, and female deposition from each allele, signifying differential expression from an autosome.

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Sept. 9, 2025, 5:42 p.m.