cubeECHACRX: Inheritance Cube: ECHACRX

In MGDrivE: Mosquito Gene Drive Explorer

Description

This function creates an X-linked ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.

• W: Wild-type

• H: Homing allele

• E: Eraser allele

• R: No-cost resistance allele

• B: Detrimental resistance allele

• cHW: Rate of homing from H, W -> H transition

• cEH: Rate of homing from E, H -> E transition

• cEW2: Rate of homing from E, W -> E transition

Usage

cubeECHACRX(
  cHW = 1,
  cEHW = 1,
  cEW1 = 1,
  cEW2 = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  chEHW = 0,
  crEHW = 0,
  ceEW1 = 0,
  crEW1 = 0,
  ceEW2 = 0,
  crEW2 = 0,
  ceEH = 0,
  crEH = 0,
  d1 = 0,
  d2 = 0,
  d3 = 0,
  dHW = 0,
  dEH = 0,
  dEW = 0,
  drHW = 0,
  drEH = 0,
  drEW = 0,
  crossF = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

cHW	Cutting efficiency of drive allele at locus 1
cEHW	Cutting efficiency of drive allele, in the presence of ECHACR element, at locus 1
cEW1	Cutting efficiency of ECHACR element into W at locus 1
cEW2	Cutting efficiency of ECHACR element into W at locus 2
cEH	Cutting efficiency of ECHACR element into H
chHW	Homing efficiency of drive allele at locus 1
crHW	Resistance allele efficiency of drive allele at locus 1
chEHW	Homing efficiency of drive allele, in the presence of ECHACR element, at locus 1
crEHW	Resistance allele efficiency of drive allele, in the presence of ECHACR element, at locus 1
ceEW1	Homing efficiency of ECHACR element into W at locus 1
crEW1	Resistance allele efficiency of ECHACR element into W at locus 1
ceEW2	Homing efficiency of ECHACR element into W at locus 2
crEW2	Resistance allele efficiency of ECHACR element into W at locus 2
ceEH	Homing efficiency of ECHACR element into H
crEH	Resistance allele efficiency of ECHACR element into H
d1	Background mutation rate from W into R allele
d2	Background mutation rate from H into R allele
d3	Background mutation rate from E into R allele
dHW	Female H deposition rate against W
dEH	Female E deposition rate against H
dEW	Female E deposition rate against W
drHW	Female resistance generation rate, from H allele
drEH	Female resistance generation rate, from E allele
drEW	Female resistance generation rate, from E allele
crossF	Female crossover rate. 0 is fully linked, 0.5 is unlinked, 1 is negatively linked
eta	Genotype-specific mating fitness
phi	Genotype-specific sex ratio at emergence
omega	Genotype-specific multiplicative modifier of adult mortality
xiF	Genotype-specific female pupatory success
xiM	Genotype-specific male pupatory success
s	Genotype-specific fractional reduction(increase) in fertility

Details

This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives publication.

Value

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

MGDrivE documentation built on Oct. 23, 2020, 7:28 p.m.