View source: R/Cube-SplitDriveY.R
cubeSplitDriveY | R Documentation |
This is a Y-linked version of a split CRISPR drive. At the Y-locus is the Cas9, inherited in a Mendelian fashion. At a second, unlinked, autosomal locus are the gRNAs. When the two loci occur together (i.e. in males), the gRNAs drive, with potential damaged alleles, but the Cas9 remains Mendelian. This drive has 2 loci:
"Locus" 1, sex chromosomes, has 3 alleles:
X: Wild-type X chromosome
Y: Wild-type Y chromosome
C: Y chromosome with Cas9
Locus 2, autosomal locus, has 4 alleles:
W: Wild-type allele
G: gRNA allele
R: Functional or low-cost resistance allele
B: Non-functional or high-cost resistance allele
cubeSplitDriveY(
cM = 1,
chM = 0,
crM = 0,
eta = NULL,
phi = NULL,
omega = NULL,
xiF = NULL,
xiM = NULL,
s = NULL
)
cM |
Cutting efficiency in males |
chM |
Homing efficiency in males |
crM |
Resistance efficiency in males |
eta |
Genotype-specific mating fitness |
phi |
Genotype-specific sex ratio at emergence |
omega |
Genotype-specific multiplicative modifier of adult mortality |
xiF |
Genotype-specific female pupatory success |
xiM |
Genotype-specific male pupatory success |
s |
Genotype-specific fractional reduction(increase) in fertility |
Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.
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