Note that backward compatibility of function arguments will not be (near-)guaranteed until version 1.0. Argument and function changes will continue until then. These will be especially noticeable around the inclusion of IV NCA parameters and additional specifications of the dosing including dose amount and route.
pk.calc.aucpext()
was made so that it now returns
NA_real_
instead of NaN
.NA
.aucabove.trough.all
was added to calculate the NCA above the
trough concentration.units
argument to the PKNCAdata()
function and the function
pknca_units_table()
.impute
argument to
the PKNCAdata()
function and the Data Imputation vignette.summary()
on a PKNCAresults object shows the units in the column
heading.as.data.frame()
on a PKNCAresults object with the argument
out.format="wide"
, if standardized units values are available, they will
be used. And if any unit are available, they will be in the column names.summary()
.pretty_names=FALSE
when
calling the summary()
function.pk.calc.time_above()
now uses the default AUC calculation method for
interpolation of time above. And, it can use 'lin up/log down' interpolation.conc_above
as a column to the intervals to allow calculation of
time_above
. With this change, the "conc_above" PKNCA.options()
value has
been removed.getData()
functions were removed.getDataName()
function for PKNCAdata objects was removed.interpolate.conc()
and interp.extrap.conc()
now give more errors with
missing (NA) input. This should not affect typical NCA (where NA values are
dropped), but it may affect direct calls to the functions themselves.time_calc()
function will help convert time values to be
relative to events (such as calculating time after and before doses).lm.fit()
instead of
lm()
decreasing time for a full NCA run by ~30% (and half-life by ~50%).plot.PKNCAconc()
was moved to the pknca.reporting package
(https://github.com/billdenney/pknca.reporting)summary.PKNCAresults()
now provides a caption
including the summary method for each parameter. If you change
summary functions using PKNCA.set.summary()
, you must now use the
description
option to set the description of the summary.PKNCAdata()
(fix #72)PKNCAresults
objects.PKNCAdata()
is more restrictive on unknown arguments issuing an error
when unknown arguments are present.intervals
argument to PKNCAdata()
may now be a tibble (fixes #72).pk.nca
(Fix #68)BACKWARD INCOMPATIBILITY: Functions that previously may have returned Infinity due to dividing by zero (e.g. when AUC=0 calculating clearance) now return NA.
Added Validation vignette.
Corrected issue where time to steady-state with a single estimate may have given more than one estimated time to steady-state.
This release is not backward compatible. The switch to observed and predicted-related NCA parameters (like aucinf.obs and aucinf.pred) changed the format of the intervals specification.
First release targeting CRAN
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