exclude_nca: Exclude NCA parameters based on examining the parameter set.

In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Exclude NCA parameters based on examining the parameter set.

Description

Exclude NCA parameters based on examining the parameter set.

Usage

exclude_nca_span.ratio(min.span.ratio)

exclude_nca_max.aucinf.pext(max.aucinf.pext)

exclude_nca_count_conc_measured(
  min_count,
  exclude_param_pattern = c("^aucall", "^aucinf", "^aucint", "^auciv", "^auclast",
    "^aumc", "^sparse_auc")
)

exclude_nca_min.hl.r.squared(min.hl.r.squared)

exclude_nca_tmax_early(tmax_early = 0)

exclude_nca_tmax_0()

Arguments

min.span.ratio	The minimum acceptable span ratio (uses PKNCA.options("min.span.ratio") if not provided).
max.aucinf.pext	The maximum acceptable percent AUC extrapolation (uses PKNCA.options("max.aucinf.pext") if not provided).
min_count	Minimum number of measured concentrations
exclude_param_pattern	Character vector of regular expression patterns to exclude
min.hl.r.squared	The minimum acceptable r-squared value for half-life (uses PKNCA.options("min.hl.r.squared") if not provided).
tmax_early	The time for Tmax which is considered too early to be a valid NCA result

Functions

• exclude_nca_span.ratio(): Exclude based on span.ratio

• exclude_nca_max.aucinf.pext(): Exclude based on AUC percent extrapolated (both observed and predicted)

• exclude_nca_count_conc_measured(): Exclude AUC measurements based on count of concentrations measured and not below the lower limit of quantification

• exclude_nca_min.hl.r.squared(): Exclude based on half-life r-squared

• exclude_nca_tmax_early(): Exclude based on implausibly early Tmax (often used for extravascular dosing with a Tmax value of 0)

• exclude_nca_tmax_0(): Exclude based on implausibly early Tmax (special case for tmax_early = 0)

See Also

Other Result exclusions: exclude()

Examples

my_conc <- PKNCAconc(data.frame(conc=1.1^(3:0),
                                time=0:3,
                                subject=1),
                     conc~time|subject)
my_data <- PKNCAdata(my_conc,
                     intervals=data.frame(start=0, end=Inf,
                                          aucinf.obs=TRUE,
                                          aucpext.obs=TRUE))
my_result <- pk.nca(my_data)
my_result_excluded <- exclude(my_result,
                              FUN=exclude_nca_max.aucinf.pext())
as.data.frame(my_result_excluded)

PKNCA documentation built on June 8, 2025, 10:48 a.m.