Calculation interval specifications are data frames defining what calculations will be required and summarized from all time intervals. Note: parameters which are not requested may be calculated if it is required for (or computed at the same time as) a requested parameter.

1 |

`x` |
The data frame specifying what to calculate during each time interval |

The data frame columns (with variable type in parentheses) are:

`start`

The starting time (numeric)

`end`

The ending time (numeric including Inf)

`aucinf`

Compute AUCinf (logical)

`auclast`

Compute AUClast (logical)

`aucall`

Compute AUCall (logical)

`aumcinf`

Compute AUMCinf (logical)

`aumclast`

Compute AUMClast (logical)

`aumcall`

Compute AUMCall (logical)

`tfirst`

The time of the first concentration above the limit of quantification (logical)

`tmax`

The time of observed maximum concentration (logical)

`tlast`

The time of the last concentration above the limit of quantification (logical)

`cmin`

The observed minimum concentration during the interval (logical)

`cmax`

The observed maximum concentration (logical)

`clast.obs`

The observed last concentration (logical)

`clast.pred`

The concentration at

`tlast`

predicted by the half life (logical)`half.life`

The half-life (logical)

`thalf.eff`

The effective half-life (logical)

`aucpext`

The percent of the AUCinf that is extrapolated after the AUClast (logical)

`cl`

The clearance (force: 'force' indicates that clearance should be calculated even if it is a multiple-dose study and the drug has not reached steady-state.)

`mrt`

The mean residence time (logical)

`vz`

Terminal volume of distribution (logical)

`vss`

Steady-state volume of distribution (logical)

The variable types for each column are:

- logical
A logical variable.

- numeric
A numeric (non-factor) column

- force
logical or the text

`'force'`

.`'force'`

indicates that checking if the calculation is appropriate should be skipped.- character or factor
The text suggested as either a character or a factor

`start`

and `end`

time must always be given, and the
`start`

must be before the `end`

.

x The potentially updated data frame with the interval calculation specification.

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