Check the formatting of a calculation interval specification data frame.
Calculation interval specifications are data frames defining what calculations will be required and summarized from all time intervals. Note: parameters which are not requested may be calculated if it is required for (or computed at the same time as) a requested parameter.
The data frame specifying what to calculate during each time interval
The data frame columns (with variable type in parentheses) are:
The starting time (numeric)
The ending time (numeric including Inf)
Compute AUCinf (logical)
Compute AUClast (logical)
Compute AUCall (logical)
Compute AUMCinf (logical)
Compute AUMClast (logical)
Compute AUMCall (logical)
The time of the first concentration above the limit of quantification (logical)
The time of observed maximum concentration (logical)
The time of the last concentration above the limit of quantification (logical)
The observed minimum concentration during the interval (logical)
The observed maximum concentration (logical)
The observed last concentration (logical)
The concentration at
tlastpredicted by the half life (logical)
The half-life (logical)
The effective half-life (logical)
The percent of the AUCinf that is extrapolated after the AUClast (logical)
The clearance (force: 'force' indicates that clearance should be calculated even if it is a multiple-dose study and the drug has not reached steady-state.)
The mean residence time (logical)
Terminal volume of distribution (logical)
Steady-state volume of distribution (logical)
The variable types for each column are:
A logical variable.
A numeric (non-factor) column
logical or the text
'force'indicates that checking if the calculation is appropriate should be skipped.
- character or factor
The text suggested as either a character or a factor
end time must always be given, and the
start must be before the
x The potentially updated data frame with the interval calculation specification.