Check the formatting of a calculation interval specification data frame.

Description

Calculation interval specifications are data frames defining what calculations will be required and summarized from all time intervals. Note: parameters which are not requested may be calculated if it is required for (or computed at the same time as) a requested parameter.

Usage

1

Arguments

x

The data frame specifying what to calculate during each time interval

Details

The data frame columns (with variable type in parentheses) are:

start

The starting time (numeric)

end

The ending time (numeric including Inf)

aucinf

Compute AUCinf (logical)

auclast

Compute AUClast (logical)

aucall

Compute AUCall (logical)

aumcinf

Compute AUMCinf (logical)

aumclast

Compute AUMClast (logical)

aumcall

Compute AUMCall (logical)

tfirst

The time of the first concentration above the limit of quantification (logical)

tmax

The time of observed maximum concentration (logical)

tlast

The time of the last concentration above the limit of quantification (logical)

cmin

The observed minimum concentration during the interval (logical)

cmax

The observed maximum concentration (logical)

clast.obs

The observed last concentration (logical)

clast.pred

The concentration at tlast predicted by the half life (logical)

half.life

The half-life (logical)

thalf.eff

The effective half-life (logical)

aucpext

The percent of the AUCinf that is extrapolated after the AUClast (logical)

cl

The clearance (force: 'force' indicates that clearance should be calculated even if it is a multiple-dose study and the drug has not reached steady-state.)

mrt

The mean residence time (logical)

vz

Terminal volume of distribution (logical)

vss

Steady-state volume of distribution (logical)

The variable types for each column are:

logical

A logical variable.

numeric

A numeric (non-factor) column

force

logical or the text 'force'. 'force' indicates that checking if the calculation is appropriate should be skipped.

character or factor

The text suggested as either a character or a factor

start and end time must always be given, and the start must be before the end.

Value

x The potentially updated data frame with the interval calculation specification.

See Also

check.interval.deps

Want to suggest features or report bugs for rdrr.io? Use the GitHub issue tracker.