interp.extrap.conc: Interpolate concentrations between measurements or...

In PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Interpolate concentrations between measurements or extrapolate concentrations after the last measurement.

Description

interpolate.conc() and extrapolate.conc() returns an interpolated (or extrapolated) concentration. interp.extrap.conc() will choose whether interpolation or extrapolation is required and will also operate on many concentrations. These will typically be used to estimate the concentration between two measured concentrations or after the last measured concentration. Of note, these functions will not extrapolate prior to the first point.

Usage

interp.extrap.conc(
  conc,
  time,
  time.out,
  lambda.z = NA,
  clast = pk.calc.clast.obs(conc, time),
  options = list(),
  interp.method = NULL,
  extrap.method = "AUCinf",
  ...,
  conc.blq = NULL,
  conc.na = NULL,
  check = TRUE
)

interpolate.conc(
  conc,
  time,
  time.out,
  options = list(),
  interp.method = NULL,
  conc.blq = NULL,
  conc.na = NULL,
  conc.origin = 0,
  ...,
  check = TRUE
)

extrapolate.conc(
  conc,
  time,
  time.out,
  lambda.z = NA,
  clast = pk.calc.clast.obs(conc, time),
  extrap.method = "AUCinf",
  options = list(),
  conc.na = NULL,
  conc.blq = NULL,
  ...,
  check = TRUE
)

interp.extrap.conc.dose(
  conc,
  time,
  time.dose,
  route.dose = "extravascular",
  duration.dose = NA,
  time.out,
  out.after = FALSE,
  options = list(),
  conc.blq = NULL,
  conc.na = NULL,
  ...,
  check = TRUE
)

Arguments

conc	Measured concentrations
time	Time of the concentration measurement
time.out	Time when interpolation is requested (vector for interp.extrap.conc(), scalar otherwise)
lambda.z	The elimination rate constant. NA will prevent extrapolation.
clast	The last observed concentration above the limit of quantification. If not given, clast is calculated from pk.calc.clast.obs()
options	List of changes to the default PKNCA.options() for calculations.
interp.method	The method for interpolation (either "lin up/log down" or "linear")
extrap.method	The method for extrapolation: "AUCinf", "AUClast", or "AUCall". See details for usage.
...	Additional arguments passed to interpolate.conc() or extrapolate.conc().
conc.blq	How to handle BLQ values. (See clean.conc.blq() for usage instructions.)
conc.na	How to handle NA concentrations. (See clean.conc.na())
check	Run check.conc.time(), clean.conc.blq(), and clean.conc.na()?
conc.origin	The concentration before the first measurement. conc.origin is typically used to set predose values to zero (default), set a predose concentration for endogenous compounds, or set predose concentrations to NA if otherwise unknown.
time.dose	Time of the dose
route.dose	What is the route of administration ("intravascular" or "extravascular"). See the details for how this parameter is used.
duration.dose	What is the duration of administration? See the details for how this parameter is used.
out.after	Should interpolation occur from the data before (FALSE) or after (TRUE) the interpolated point? See the details for how this parameter is used. It only has a meaningful effect at the instant of an IV bolus dose.

Details

extrap.method

'AUCinf'

Use lambda.z to extrapolate beyond the last point with the half-life.

'AUCall'

If the last point is above the limit of quantification or missing, this is identical to 'AUCinf'. If the last point is below the limit of quantification, then linear interpolation between the Clast and the next BLQ is used for that interval and all additional points are extrapolated as 0.

'AUClast'

Extrapolates all points after the last above the limit of quantification as 0.

duration.dose and direction.out are ignored if route.dose == "extravascular". direction.out is ignored if duration.dose > 0.

route.dose and duration.dose affect how interpolation/extrapolation of the concentration occurs at the time of dosing. If route.dose == "intravascular" and duration.dose == 0 then extrapolation occurs for an IV bolus using pk.calc.c0() with the data after dosing. Otherwise (either route.dose == "extravascular" or duration.dose > 0), extrapolation occurs using the concentrations before dosing and estimating the half-life (or more precisely, estimating lambda.z). Finally, direction.out can change the direction of interpolation in cases with route.dose == "intravascular" and duration.dose == 0. When direction.out == "before" interpolation occurs only with data before the dose (as is the case for route.dose == "extravascular"), but if direction.out == "after" interpolation occurs from the data after dosing.

Value

The interpolated or extrapolated concentration value as a scalar double (or vector for interp.extrap.conc()).

Functions

• interpolate.conc(): Interpolate concentrations through Tlast (inclusive)

• extrapolate.conc(): Extrapolate concentrations after Tlast

• interp.extrap.conc.dose(): Interpolate and extrapolate concentrations without interpolating or extrapolating beyond doses.

See Also

pk.calc.clast.obs(), pk.calc.half.life(), pk.calc.c0()

PKNCA documentation built on April 30, 2023, 1:08 a.m.