filterOutIterations: Remove Iterations that Generated Outlier Results.

In mutSignatures: Decipher Mutational Signatures from Somatic Mutational Catalogs

Description

Internal function from the WTSI framework, ported to R. This is a core function called from within a deconvoluteMutCounts() call. This function removes iterations that generated outlier results.

Usage

filterOutIterations(wall, hall, cnt_errors, cnt_reconstructed, params)

Arguments

wall	numeric matrix combining w results from all iterations
hall	numeric matrix combining h results from all iterations
cnt_errors	numeric matrix combining all residuals from all iterations
cnt_reconstructed	numeric matrix combining fitted values from all iterations
params	list including alll parameters for running the analysis

Details

This is one of the core functions included in the original mutSignatures R library, and in the WTSI MATLAB framework. This is an internal function.

Value

list including all data required for running the subsequent stability check

Author(s)

Damiano Fantini, [e-mail]

References

More information and examples about mutational signature analysis can be found here:

1. GitHub Repo: https://github.com/dami82/mutSignatures/

2. More info and examples about the mutSignatures R library: https://www.data-pulse.com/dev_site/mutsignatures/

3. Sci Rep paper, introducing mutS: https://www.nature.com/articles/s41598-020-75062-0/

4. Oncogene paper, Mutational Signatures Operative in Bladder Cancer: https://www.nature.com/articles/s41388-017-0099-6

5. WTSI framework: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588146/

mutSignatures documentation built on Nov. 9, 2020, 9:06 a.m.