mutSignatures-package: Computational Framework for Deciphering Cancer Mutational...

Description Details Author(s) Examples

Description

Accumulation of DNA mutations is a hallmark of cancer. Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework allows to characterize mutational signatures from cancer-derived somatic mutational catalogs

Details

Please, cite the following article when using this software: Fantini D et al, Mol Biol Cell. 2017 Jan 1;28(1):192-200. More info at: http://www.biotechworld.it/bioinf/2017/01/22/mutsignatures/ Software developed in the Meeks Lab, Dept. of Urology, Northwestern University, Chicago, USA This is a R implementation of the original MATLAB framework described here: Cell Rep. 2013 Jan 31;3(1):246-59.

Author(s)

Damiano Fantini, Joshua J Meeks Maintainer: Damiano Fantini <[email protected]>

Examples

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  citation()
  ## Not run: 
  tmp <- getTestRunArgs()
  result <- extractSignatures(mutCountMatrix = tmp$mutCount.obj$mutCounts, params = tmp$params)
  result
  plotSignatureExposures(results)
  
## End(Not run)

mutSignatures documentation built on May 30, 2017, 1:32 a.m.