Description Usage Arguments Details Value Author(s) References
View source: R/s03_all_functions.R
Analyze the similarity between mutational signatures from different analyses/runs. THis function can be helpful to match de novo extracted signatures with previously described signatures (such as COSMIC), or to reveal signatures that can be identified with alternative NMF algorithms, or that may be due to an algorithm bias.
1 2 3 4 5 6 7 | matchSignatures(
mutSign,
reference = NULL,
method = "cosine",
threshold = 0.5,
plot = "TRUE"
)
|
mutSign |
a mutationSignatures object |
reference |
a mutationSignatures object. If NULL, COSMIC signatures will be retrieved |
method |
distance method used to compute similarity (1 - distance) |
threshold |
signal (similarity) upper threshold for maxing the signal |
plot |
logical, shall a heatmap be plotted |
This function is part of the user-interface set of tools included in mutSignatures. This is an exported function.
list, including distance matrix and a heatmap plot
Damiano Fantini, damiano.fantini@gmail.com
More information and examples about mutational signature analysis can be found here:
GitHub Repo: https://github.com/dami82/mutSignatures/
More info and examples about the mutSignatures R library: https://www.data-pulse.com/dev_site/mutsignatures/
Sci Rep paper, introducing mutS: https://www.nature.com/articles/s41598-020-75062-0/
Oncogene paper, Mutational Signatures Operative in Bladder Cancer: https://www.nature.com/articles/s41388-017-0099-6
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.