analyse_inherited_enrichment: test for enrichment of inherited variants

In jeremymcrae/recessiveStats: Enrichment of recessive variants within genes

Description

test for enrichment of inherited variants

Usage

analyse_inherited_enrichment(counts, variants, cohort_n = 3072,
  autozygosity = 0, threshold = 0.01)

Arguments

counts	list of counts of biallelically inherited genotypes in a gene for: 1) biallelic_lof - inherited Lof/LoF variants, 2) lof_func - ninherited Lof/Func variants, 3) biallelic_func inherited func/func variants. 4) all all inherited LoF/LoF, LoF/func or func/func variants.
variants	dataframe of variants in gene
cohort_n	number of probands in population.
autozygosity	rate of autozygosity within the gene in the probands.
threshold	threshold for minor allele frequency, above which we exclude variants.

Value

a list of P values from LoF and functional tests.

jeremymcrae/recessiveStats documentation built on May 19, 2019, 5:08 a.m.