biallelic_syn_enrichment: test enrichment of inherited biallelic synonymous variants

In jeremymcrae/recessiveStats: Enrichment of recessive variants within genes

Description

test enrichment of inherited biallelic synonymous variants

Usage

biallelic_syn_enrichment(freq, count, cohort_n, autozygosity = 0)

Arguments

freq	list of cumulative frequencies of variation in a population for rare LoF variants, and rare functional variants.
count	number of probands with inherited variants in the gene.
cohort_n	number of probands in population.
autozygosity	rate of autozygosity in the cohort being investigated.

Value

P-value from testing for biallelic synonymous variants.

Examples

freq = list(lof=0.001, functional=0.1, synonymous=0.3)
count = 3
biallelic_syn_enrichment(freq, count, 1000)

jeremymcrae/recessiveStats documentation built on May 19, 2019, 5:08 a.m.