biallelic_lof_enrichment: test for enrichment of biallelic LoF inherited variants

In jeremymcrae/recessiveStats: Enrichment of recessive variants within genes

Description

test for enrichment of biallelic LoF inherited variants

Usage

biallelic_lof_enrichment(freq, count, cohort_n, autozygosity = 0)

Arguments

freq	list of cumulative frequencies of variation in a population for rare LoF variants, and rare functional variants.
count	number of probands with inherited variants in the gene.
cohort_n	number of probands in population.
autozygosity	rate of autozygosity in the cohort being investigated.

Value

P-value from testing for biallelic LoF variants.

Examples

freq = list(lof=0.001, functional=0.1)
count = 3
biallelic_lof_enrichment(freq, count, 1000)

jeremymcrae/recessiveStats documentation built on May 19, 2019, 5:08 a.m.