Description Usage Arguments Value Examples
View source: R/alleles_recessive_test.R
test for enrichment of inherited variants
1 | enrichment_single_population(freq, counts, cohort_n, autozygosity = 0)
|
freq |
list of cumulative frequencies of variation in a population for rare LoF variants, and rare functional variants. |
counts |
list of counts of biallelically inherited genotypes in a gene for: 1) biallelic_lof - inherited Lof/LoF variants, 2) lof_func - ninherited Lof/Func variants, 3) biallelic_func inherited func/func variants. |
cohort_n |
number of probands in population. |
autozygosity |
rate of autozygosity in the cohort being investigated. |
a list of P values from tests, under LoF and functional tests.
1 2 3 | freq = list(lof=0.001, functional=0.1)
counts = list("biallelic_lof"=1, 'biallelic_func'=4, 'lof_func'=2)
enrichment_single_population(freq, counts, 1000)
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