sum_combo_tests: get a p-value that sums across different population...

In jeremymcrae/recessiveStats: Enrichment of recessive variants within genes

Description

get a p-value that sums across different population possibilities

Usage

sum_combo_tests(freqs, cohort_n, combos, enrich_function, autozygosity = 0)

Arguments

freqs	list of frequency estimates for each ExAC population.
cohort_n	list of number of probands in each population.
combos	a dataframe of the possible count combinations for a functional type.
enrich_function	function to test enrichment.
autozygosity	rate of autozygosity in the cohort being investigated.

Value

a p-value from testing for

Examples

freqs = list("A"=list("lof"=0.1, "functional"=0.1),
    "B"=list("lof"=0.1, "functional"=0.1))
cohort_n = list("A"=100, "B"=100)
combos = get_count_combinations(names(cohort_n), count=1)
sum_combo_tests(freqs, cohort_n, combos, biallelic_lof_enrichment)

jeremymcrae/recessiveStats documentation built on May 19, 2019, 5:08 a.m.