Description Usage Arguments Value Examples

View source: R/alleles_recessive_test.R

get a p-value that sums across different population possibilities

1 | ```
sum_combo_tests(freqs, cohort_n, combos, enrich_function, autozygosity = 0)
``` |

`freqs` |
list of frequency estimates for each ExAC population. |

`cohort_n` |
list of number of probands in each population. |

`combos` |
a dataframe of the possible count combinations for a functional type. |

`enrich_function` |
function to test enrichment. |

`autozygosity` |
rate of autozygosity in the cohort being investigated. |

a p-value from testing for

1 2 3 4 5 | ```
freqs = list("A"=list("lof"=0.1, "functional"=0.1),
"B"=list("lof"=0.1, "functional"=0.1))
cohort_n = list("A"=100, "B"=100)
combos = get_count_combinations(names(cohort_n), count=1)
sum_combo_tests(freqs, cohort_n, combos, biallelic_lof_enrichment)
``` |

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