plotLMEM: Plot Volcano Plots of LMEM Log2FC Results

View source: R/plotLMEM.R

plotLMEMR Documentation

Plot Volcano Plots of LMEM Log2FC Results

Description

Plot Volcano Plots of LMEM Log2FC Results

Usage

plotLMEM(
  dataset = NULL,
  formula = NULL,
  exclude = NULL,
  rank = NULL,
  zero.handling = "pseudo-count",
  alpha = 0.05,
  fc = 1.5,
  is.winsor = T
)

Arguments

dataset

MicroVis dataset. Defaults to active dataset.

formula

Formula for linear model. Defaults to simple linear model of all covariates.

exclude

Factors/covariates to exclude in linear model.

rank

Rank at which to conduct analysis.

zero.handling

(From linda function) A character string of 'pseudo-count' or 'imputation' indicating the zero handling method used when feature.dat is 'count'. If 'pseudo-count', apseudo.cnt will be added to each value in feature.dat. If 'imputation', then we use the imputation approach using the formula in the referenced paper. Basically, zeros are imputed with values proportional to the sequencing depth. When feature.dat is 'proportion', this parameter will be ignored and zeros will be imputed by half of the minimum for each feature.

alpha

Significance threshold. Defaults to 0.05

fc

Fold-change threshold.

is.winsor

Whether to replace outliers (using winsorization)

Value

Volcano plots of log2fc values for each feature for groups in each covariate


microresearcher/MicroVis documentation built on Feb. 8, 2024, 10:59 a.m.