music.iter: Scaling bulk data and signature matrix and estimate cell type...

In xuranw/MuSiC: Multi-subject single cell deconvolution

Scaling bulk data and signature matrix and estimate cell type proportion

Description

Scaling bulk data and signature matrix and estimate cell type proportion

Usage

music.iter(
  Y,
  D,
  S,
  Sigma,
  iter.max = 1000,
  nu = 1e-04,
  eps = 0.01,
  centered = FALSE,
  normalize = FALSE
)

Arguments

Y	vector of bulk tissue expression
D	matrix, Signature matrix
S	vector of Avg. Library size
Sigma	matrix of subject level variation (gene * cell type)
iter.max	numeric, maximum iteration number
nu	regulation parameter, when take reciprocal
eps	threshold of convergence
centered	logic, subtract avg of Y and D
normalize	logic, divide Y and D by their standard deviation

Value

a list same as nnls.weight.basic

xuranw/MuSiC documentation built on March 7, 2024, 11:45 a.m.