This function simplifies the process of sweeping the modal log R
ratio from the rows or columns of a
object. It is most useful when a large number of samples (more
than 10) are available and the dataset is a collection of germline
samples. We assume that the samples are from a single batch and
that the modal value will be a robust estimate of the mean log R
ratio for diploid copy number. Variation in the modal estimates
between markers is presumed to be attributable to probe effects
(e.g., differences hybridization efficiency/PCR do to sequence
composition). For sex chromosomes, one should apply this function
separately to men and women and then recenter the resulting matrix
according to the expected copy number.
1 2 3 4
integer indicating which margin (1=rows, 2=columns) to sweep the mode
an object of the same class as
1 2 3 4 5 6
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