isHeterozygous: Assess whether genotype is heterozygous based on BAFs

In VanillaICE: A Hidden Markov Model for high throughput genotyping arrays

Description

Assess whether genotype is heterozygous based on BAFs

Usage

isHeterozygous(object, cutoff)

## S4 method for signature 'ArrayViews'
isHeterozygous(object, cutoff)

## S4 method for signature 'SnpArrayExperiment'
isHeterozygous(object, cutoff)

## S4 method for signature 'numeric'
isHeterozygous(object, cutoff)

## S4 method for signature 'matrix'
isHeterozygous(object, cutoff)

Arguments

object	a SnpArrayExperiment or ArrayViews object containing BAFs, a matrix of BAFs, or a numeric vector of BAFs. vector of BAFs
cutoff	a length-two numeric vector providing the range of BAFs consistent with allelic heterozygosity

Examples

if(require("BSgenome.Hsapiens.UCSC.hg18")){
  bsgenome <- BSgenome.Hsapiens.UCSC.hg18
  snp_exp <- getExampleSnpExperiment(bsgenome)
  is_het <- isHeterozygous(snp_exp[, 1], c(0.4, 0.6))
  table(is_het)
}

VanillaICE documentation built on Nov. 8, 2020, 7:33 p.m.