decompTumor2Sig: Decomposition of individual tumors into mutational signatures by signature refitting

Uses quadratic programming for signature refitting, i.e., to decompose the mutation catalog from an individual tumor sample into a set of given mutational signatures (either Alexandrov-model signatures or Shiraishi-model signatures), computing weights that reflect the contributions of the signatures to the mutation load of the tumor.

Package details

AuthorRosario M. Piro [aut, cre], Sandra Krueger [ctb]
Bioconductor views BiologicalQuestion BiomedicalInformatics DNASeq Genetics GenomicVariation SNP Sequencing Software SomaticMutation StatisticalMethod
MaintainerRosario M. Piro <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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decompTumor2Sig documentation built on Nov. 8, 2020, 8:23 p.m.