Description Usage Arguments References Examples
View source: R/ThreeComp_Coefficient_Exponent.R
Calculate pharmacokinetic parameters with parameters (A, B, C, alpha, beta, and gamma) in two compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"
1 2 3 4 5 |
A |
parameter in one compartment model "Aexp(-alpha)" |
B |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
C |
parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)" |
alpha |
parameter in one compartment model "Aexp(-alpha)" |
beta |
parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)" |
gamma |
parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)" |
A.sd |
standard error of A |
B.sd |
standard error of B |
C.sd |
standard error of C |
alpha.sd |
standard error of alpha |
beta.sd |
standard error of beta |
gamma.sd |
standard error of gamma |
covar |
covariances among parameters |
... |
arguments to be passed to methods |
http://www.nonmemcourse.com/convert.xls
1 2 3 | ThreeComp_Coefficient_Exponent(A=12.2,B=3.76,C=1.44,
alpha=0.870,beta=0.12,gamma=0.013, A.sd=0.2,B.sd=0.005,C.sd=0.0005,
alpha.sd=0.009,beta.sd=0.006,gamma.sd=0.00005)
|
Parameter Estimate Std.err
Vdss Vdss 0.360938323 6.474356e-03
V1 V1 0.057471264 6.607977e-04
V2 V2 0.064978278 2.491319e-03
V3 V3 0.238488780 9.000084e-03
Cl1 Cl1 0.006405101 6.757429e-05
Cl2 Cl2 0.021376282 6.971502e-04
Cl3 Cl3 0.008828208 5.749821e-04
k10 k10 0.111448765 1.613078e-03
k12 k12 0.371947306 1.144533e-02
k21 k21 0.328975813 5.190621e-03
k13 k13 0.153610825 1.007924e-02
k31 k31 0.037017290 1.075726e-03
alpha alpha 0.870000000 9.000000e-03
beta beta 0.120000000 6.000000e-03
gamma gamma 0.013000000 5.000000e-05
t_alpha t_alpha 0.796720897 8.241940e-03
t_beta t_beta 5.776226505 2.888113e-01
t_gamma t_gamma 53.319013889 2.050731e-01
True_A True_A 12.200000000 2.000000e-01
True_B True_B 3.760000000 5.000000e-03
True_C True_C 1.440000000 5.000000e-04
Frac_A Frac_A 0.701149425 3.441027e-03
Frac_B Frac_B 0.216091954 2.494017e-03
Frac_C Frac_C 0.082758621 9.519107e-04
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