TwoComp_Volume_RateConstant: Convert pharmacokinetic parameters for two compartment model

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k21)

Usage

TwoComp_Volume_RateConstant(V1,k10,k12,k21,
              V1.sd=NA,k10.sd=NA,k12.sd=NA,k21.sd=NA,
              covar=c(V1k10=NA,V1k12=NA,V1k21=NA,
              k10k12=NA,k10k21=NA,k12k21=NA),...)

Arguments

V1	The volume of distribution of compartment 1
k10	elimination rate constant
k12	transfer rate constants from compartment 1 to compartment 2
k21	transfer rate constants from compartment 2 to compartment 1
V1.sd	standard error of V1
k10.sd	standard error of k10
k12.sd	standard error of k12
k21.sd	standard error of k21
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_RateConstant(V1=5,k10=0.7,k12=0.5,k21=0.05,
         V1.sd=0.01,k10.sd=0.002,k12.sd=0.001,k21.sd=0.0005)

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.