TwoComp_Coefficient_Exponent: Convert pharmacokinetic parameters for two compartment model

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with parameters (A, B, alpha and beta) in two compartment model "Aexp(-alpha)+Bexp(-beta)"

Usage

TwoComp_Coefficient_Exponent(A,B,alpha,beta,
 A.sd=NA,B.sd=NA,alpha.sd=NA,beta.sd=NA,
 covar=c(AB=NA,Aalpha=NA,Abeta=NA,Balpha=NA,Bbeta=NA,alphabeta=NA),...)

Arguments

A	parameter in one compartment model "Aexp(-alpha)"
B	parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"
alpha	parameter in one compartment model "Aexp(-alpha)"
beta	parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"
A.sd	standard error of A
B.sd	standard error of B
alpha.sd	standard error of alpha
beta.sd	standard error of beta
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Coefficient_Exponent(A=0.196,B=0.0036,alpha=1.221,beta=0.0287,
A.sd=0.002,B.sd=0.00005,alpha.sd=0.09,beta.sd=0.0006)

Example output

        Parameter    Estimate      Std.err
Vdss         Vdss 55.05543958 4.5318394469
V1             V1  5.01002004 0.0502162868
V2             V2 50.04541954 4.5253277822
Cl1           Cl1  3.49699625 0.1510647952
Cl2           Cl2  2.51250070 0.3028821274
k10           k10  0.69800045 0.0300117948
k12           k12  0.50149514 0.0600215148
k21           k21  0.05020441 0.0017647964
alpha       alpha  1.22100000 0.0900000000
beta         beta  0.02870000 0.0006000000
t_alpha   t_alpha  0.56768811 0.0418443323
t_beta     t_beta 24.15146971 0.5049087743
True_A     True_A  0.19600000 0.0020000000
True_B     True_B  0.00360000 0.0000500000
Frac_A     Frac_A  0.98196393 0.0003052345
Frac_B     Frac_B  0.01803607 0.0003052345

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.