ThreeComp_Volume_Clearance: Convert pharmacokinetic parameters for three compartment...

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distributions (V1, V2 and V3) and clearances (Cl1, Cl2, and Cl3)

Usage

ThreeComp_Volume_Clearance(V1,V2,V3,Cl1,Cl2,Cl3,
 V1.sd=NA,V2.sd=NA,V3.sd=NA, Cl1.sd=NA,Cl2.sd=NA,Cl3.sd=NA,
 covar=c(V1V2=NA,V1V3=NA,V1Cl1=NA,
   V1Cl2=NA,V1Cl3=NA,V2V3=NA,V2Cl1=NA,V2Cl2=NA,V2Cl3=NA,
   V3Cl1=NA,V3Cl2=NA,V3Cl3=NA,Cl1Cl2=NA,Cl1Cl3=NA,Cl2Cl3=NA),...)

Arguments

V1	The volume of distribution of compartment 1
V2	The volume of distribution of compartment 2
V3	The volume of distribution of compartment 3
Cl1	Clearance from compartment 1
Cl2	Clearance from compartment 2
Cl3	Clearance from compartment 3
V1.sd	standard error of V1
V2.sd	standard error of V2
V3.sd	standard error of V3
Cl1.sd	standard error of Cl1
Cl2.sd	standard error of Cl2
Cl3.sd	standard error of Cl3
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Clearance(V1=10,V2=100,V3=1000,Cl1=3,Cl2=2,Cl3=1,
  V1.sd=0.01,V2.sd=0.1,V3.sd=1,Cl1.sd=0.01,Cl2.sd=0.01,Cl3.sd=0.01)

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.