TwoComp_Volume_Clearance_HalfLife: Convert pharmacokinetic parameters for two compartment model

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), clearance (Cl1) and half-lives (t_alpha and t_beta)

Usage

TwoComp_Volume_Clearance_HalfLife(V1,Cl1,t_alpha,t_beta,
 V1.sd=NA,Cl1.sd=NA,t_alpha.sd=NA,
 t_beta.sd=NA,covar=c(V1Cl1=NA,V1talpha=NA,V1tbeta=NA,Cl1talpha=NA,
   Cl1tbeta=NA,talphatbeta=NA),...)

Arguments

V1	The volume of distribution of compartment 1
Cl1	Clearance from compartment 1
t_alpha	half life of compartment 1
t_beta	half life of compartment 2
V1.sd	standard error of V1
Cl1.sd	standard error of Cl1
t_alpha.sd	standard error of t_alpha
t_beta.sd	standard error of t_beta
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Clearance_HalfLife(V1=5,Cl1=3.5,t_alpha=0.568,t_beta=24.2,
V1.sd=0.01,Cl1.sd=0.01,t_alpha.sd=0.002,t_beta.sd=0.5)

Example output

        Parameter     Estimate      Std.err
Vdss         Vdss 54.970667315 1.111937e+00
V1             V1  5.000000000 1.000000e-02
V2             V2 49.970667315 1.110720e+00
Cl1           Cl1  3.500000000 1.000000e-02
Cl2           Cl2  2.495194069 2.545022e-02
k10           k10  0.700000000 2.441311e-03
k12           k12  0.499038814 4.724100e-03
k21           k21  0.049933175 1.060942e-03
alpha       alpha  1.220329543 4.296935e-03
beta         beta  0.028642445 5.917861e-04
t_alpha   t_alpha  0.568000000 2.000000e-03
t_beta     t_beta 24.200000000 5.000000e-01
True_A     True_A  0.196426792 4.175510e-04
True_B     True_B  0.003573208 8.159408e-05
Frac_A     Frac_A  0.982133960 4.137052e-04
Frac_B     Frac_B  0.017866040 4.137052e-04

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.