ThreeComp_Volume_RateConstant: Convert pharmacokinetic parameters for three compartment...

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distribution (V1), elimination rate constant (k10), and transter rate constants (k12, k13, k21, and k31)

Usage

ThreeComp_Volume_RateConstant(V1,k10,k12,k13,k21,k31,
 V1.sd=NA,k10.sd=NA,k12.sd=NA,
 k13.sd=NA,k21.sd=NA,k31.sd=NA,covar=c(V1k10=NA,V1k12=NA,V1k13=NA,
   V1k21=NA,V1k31=NA,k10k12=NA,k10k13=NA,k10k21=NA,k10k31=NA,
   k12k13=NA,k12k21=NA,k12k31=NA,k13k21=NA,k13k31=NA,k21k31=NA),...)

Arguments

V1	The volume of distribution of compartment 1
k10	elimination rate constant
k12	transfer rate constants from compartment 1 to compartment 2
k13	transfer rate constants from compartment 1 to compartment 3
k21	transfer rate constants from compartment 2 to compartment 1
k31	transfer rate constants from compartment 3 to compartment 1
V1.sd	standard error of V1
k10.sd	standard error of k10
k12.sd	standard error of k12
k13.sd	standard error of k13
k21.sd	standard error of k21
k31.sd	standard error of k31
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_RateConstant(V1=10,k10=0.3,k12=0.2,k13=0.1,k21=0.02,
         k31=0.001,V1.sd=0.1,k10.sd=0.002,k12.sd=0.001,
         k13.sd=0.0005,k21.sd=0.0005,k31.sd=0.000005)

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.