ThreeComp_Volume_Exponent: Convert pharmacokinetic parameters for three compartment...

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12 and k31), and parameters (alpha, beta and gamma) in the model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"

Usage

ThreeComp_Volume_Exponent(V1,alpha,beta,gamma,k21,k31,
 V1.sd=NA,alpha.sd=NA,beta.sd=NA,gamma.sd=NA,k21.sd=NA,k31.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1gamma=NA,V1k21=NA,V1k31=NA,
   alphabeta=NA,alphagamma=NA,alphak21=NA,alphak31=NA,
   betagamma=NA,betak21=NA,betak31=NA,gammak21=NA,gammak31=NA,
   k21k31=NA),...)

Arguments

V1	The volume of distribution of compartment 1
alpha	parameter in one compartment model "Aexp(-alpha)"
beta	parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"
gamma	parameter in three compartment model "Aexp(-alpha)+Bexp(-beta)+Cexp(-gamma)"
k21	transfer rate constants from compartment 2 to compartment 1
k31	transfer rate constants from compartment 3 to compartment 1
V1.sd	standard error of V1
alpha.sd	standard error of alpha
beta.sd	standard error of beta
gamma.sd	standard error of gamma
k21.sd	standard error of k21
k31.sd	standard error of k31
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

ThreeComp_Volume_Exponent(V1=10,alpha=0.6, beta=0.013, gamma=0.00074,
   k21=0.02, k31=0.001, V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,
   gamma.sd=0.000002, k21.sd=0.0006,k31.sd=0.0000005)

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.