TwoComp_Volume_Exponent: Convert pharmacokinetic parameters for two compartment model

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distribution(V1), transfer rate constant (k12), and parameters (alpha and beta) in the model "Aexp(-alpha)+Bexp(-beta)"

Usage

TwoComp_Volume_Exponent(V1,alpha,beta,k21,V1.sd=NA,
 alpha.sd=NA,beta.sd=NA,k21.sd=NA,
 covar=c(V1alpha=NA,V1beta=NA,V1k21=NA,alphabeta=NA,
 alphak21=NA,betak21=NA),...)

Arguments

V1	The volume of distribution of compartment 1
alpha	parameter in one compartment model "Aexp(-alpha)"
beta	parameter in two compartment model "Aexp(-alpha)+Bexp(-beta)"
k21	transfer rate constants from compartment 2 to compartment 1
V1.sd	standard error of V1
alpha.sd	standard error of alpha
beta.sd	standard error of beta
k21.sd	standard error of k21
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Exponent(V1=5,alpha=1.221, beta=0.029, k21=0.05,
V1.sd=0.01,alpha.sd=0.01,beta.sd=0.00005,k21.sd=0.0006)

Example output

        Parameter    Estimate      Std.err
Vdss         Vdss 54.18200000 0.4916381819
V1             V1  5.00000000 0.0100000000
V2             V2 49.18200000 0.4895312267
Cl1           Cl1  3.54090000 0.0522866235
Cl2           Cl2  2.45910000 0.0453761281
k10           k10  0.70818000 0.0103609635
k12           k12  0.49182000 0.0090217610
k21           k21  0.05000000 0.0006000000
alpha       alpha  1.22100000 0.0100000000
beta         beta  0.02900000 0.0000500000
t_alpha   t_alpha  0.56768811 0.0046493703
t_beta     t_beta 23.90162692 0.0412097016
True_A     True_A  0.19647651 0.0004068027
True_B     True_B  0.00352349 0.0001054800
Frac_A     Frac_A  0.98238255 0.0005262215
Frac_B     Frac_B  0.01761745 0.0005262215

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.