TwoComp_Volume_Clearance: Convert pharmacokinetic parameters for two compartment model

In PKconverter: The Parameter Converter of the Pharmacokinetic Models

Description

Calculate pharmacokinetic parameters with volume of distributions (V1 and V2) and clearances (Cl1 and Cl2)

Usage

TwoComp_Volume_Clearance(V1,V2,Cl1,Cl2,
                  V1.sd=NA,V2.sd=NA,Cl1.sd=NA,Cl2.sd=NA,
                  covar=c(V1V2=0,V1Cl1=0,V1Cl2=0,
                    V2Cl1=0,V2Cl2=0,Cl1Cl2=0),...)

Arguments

V1	The volume of distribution of compartment 1
V2	The volume of distribution of compartment 2
Cl1	Clearance from compartment 1
Cl2	Clearance from compartment 2
V1.sd	standard error of V1
V2.sd	standard error of V2
Cl1.sd	standard error of Cl1
Cl2.sd	standard error of Cl2
covar	covariances among parameters
...	arguments to be passed to methods

References

http://www.nonmemcourse.com/convert.xls

Examples

TwoComp_Volume_Clearance(V1=5,V2=50,Cl1=3.5,Cl2=2.5,
         V1.sd=0.01,V2.sd=0.1,Cl1.sd=0.01,Cl2.sd=0.01)

PKconverter documentation built on Feb. 6, 2020, 5:08 p.m.