Fleiss1993bin: Aspirin after Myocardial Infarction

Description Format Source Examples

Description

Meta-analysis on aspirin in preventing death after myocardial infarction.

Data example in Fleiss (1993) for meta-analysis with binary outcomes.

Format

A data frame with the following columns:

study study label
year year of publication
d.asp number of deaths in aspirin group
n.asp number of observations in aspirin group
d.plac number of deaths in placebo group
n.plac number of observations in placebo group

Source

Fleiss JL (1993): The statistical basis of meta-analysis. Statistical Methods in Medical Research, 2, 121–45

Examples

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data(Fleiss1993bin)
metabin(d.asp, n.asp, d.plac, n.plac,
        data = Fleiss1993bin,
        studlab = paste(study, year),
        sm = "OR", comb.random = FALSE)

Example output

Loading 'meta' package (version 4.15-1).
Type 'help(meta)' for a brief overview.
                OR           95%-CI %W(fixed)
MRC-1 1974  0.7197 [0.4890; 1.0593]       3.2
CDP 1976    0.6808 [0.4574; 1.0132]       3.1
MRC-2 1979  0.8029 [0.6065; 1.0629]       5.7
GASP 1979   0.8007 [0.4863; 1.3186]       1.8
PARIS 1980  0.7981 [0.5526; 1.1529]       3.2
AMIS 1980   1.1327 [0.9347; 1.3728]      10.2
ISIS-2 1988 0.8950 [0.8294; 0.9657]      72.9

Number of studies combined: k = 7

                       OR           95%-CI     z p-value
Fixed effect model 0.8969 [0.8405; 0.9570] -3.29  0.0010

Quantifying heterogeneity:
 tau^2 = 0.0096; tau = 0.0982; I^2 = 39.7% [0.0%; 74.6%]; H = 1.29 [1.00; 1.99]

Test of heterogeneity:
    Q d.f. p-value
 9.95    6  0.1269

Details on meta-analytical method:
- Mantel-Haenszel method
- DerSimonian-Laird estimator for tau^2
- Mantel-Haenszel estimator used in calculation of Q and tau^2 (like RevMan 5)

meta documentation built on Sept. 14, 2021, 5:14 p.m.