amlodipine: Amlodipine for Work Capacity

Description Format Source See Also Examples

Description

Meta-analysis on the effect of amlodipine on work capacity.

This meta-analysis is used as a data example in Hartung and Knapp (2001).

Format

A data frame with the following columns:

study study label
n.amlo number of observations in amlodipine group
mean.amlo estimated mean in amlodipine group
var.amlo variance in amlodipine group
n.plac number of observations in placebo group
mean.plac estimated mean in placebo group
var.plac variance in placebo group

Source

Hartung J & Knapp G (2001): On tests of the overall treatment effect in meta-analysis with normally distributed responses. Statistics in Medicine, 20, 1771–82

See Also

metacont

Examples

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data(amlodipine)

m <- metacont(n.amlo, mean.amlo, sqrt(var.amlo),
              n.plac, mean.plac, sqrt(var.plac),
              data = amlodipine, studlab = study)
s1 <- summary(m)
s2 <- summary(update(m, hakn = TRUE))

vars <- c("TE", "lower", "upper")

# Same results for mean difference as in Table III in Hartung and
# Knapp (2001)
#
res.md <- rbind(data.frame(s1$fixed)[vars],
                data.frame(s1$random)[vars],
                data.frame(s2$random)[vars])
#
res.md <- round(res.md, 5)
#
row.names(res.md) <- c("FE", "RE", "RE (HaKn)")
names(res.md) <- c("Absolute difference", "CI lower", "CI upper")
#
res.md

Example output

Loading 'meta' package (version 4.9-5).
Type 'help(meta)' for a brief overview.
          Absolute difference CI lower CI upper
FE                    0.16190  0.09860  0.22519
RE                    0.15888  0.07102  0.24674
RE (HaKn)             0.15888  0.03869  0.27907

meta documentation built on Sept. 14, 2021, 5:14 p.m.