cisapride: Cisapride in Non-Ulcer Dispepsia

Description Format Source See Also Examples

Description

Meta-analysis on cisapride in non-ulcer dispepsia.

This meta-analysis is used as a data example in Hartung and Knapp (2001).

Format

A data frame with the following columns:

study study label
event.cisa number of events in cisapride group
n.cisa number of observations in cisapride group
event.plac number of events in placebo group
n.plac number of observations in placebo group

Source

Hartung J & Knapp G (2001): A refined method for the meta-analysis of controlled clinical trials with binary outcome. Statistics in Medicine, 20, 3875–89

See Also

metabin

Examples

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data(cisapride)

m.or <- metabin(event.cisa, n.cisa, event.plac, n.plac,
                data = cisapride, sm = "OR", method = "Inverse",
                studlab = study, addincr = TRUE)

s1 <- summary(update(m.or, sm = "RR"))
s2 <- summary(update(m.or, sm = "RR", hakn = TRUE))
#
s3 <- summary(m.or)
s4 <- summary(update(m.or, hakn = TRUE))

vars <- c("TE", "lower", "upper")

# Results for log risk ratio - see Table VII in Hartung and Knapp (2001) 
#
res.rr <- rbind(data.frame(s1$fixed)[vars],
                data.frame(s1$random)[vars],
                data.frame(s2$random)[vars])
#
row.names(res.rr) <- c("FE", "RE", "RE (HaKn)")
names(res.rr) <- c("Log risk ratio", "CI lower", "CI upper")
#
res.rr


# Results for log odds ratio (Table VII in Hartung and Knapp 2001) 
#
res.or <- rbind(data.frame(s3$fixed)[vars],
                data.frame(s3$random)[vars],
                data.frame(s4$random)[vars])
#
row.names(res.or) <- c("FE", "RE", "RE (HaKn)")
names(res.or) <- c("Log odds ratio", "CI lower", "CI upper")
#
res.or

Example output

Loading 'meta' package (version 4.9-5).
Type 'help(meta)' for a brief overview.
          Log risk ratio  CI lower  CI upper
FE             0.4421856 0.3197713 0.5646000
RE             0.5574697 0.3176445 0.7972948
RE (HaKn)      0.5574697 0.2728613 0.8420780
          Log odds ratio  CI lower CI upper
FE               1.23053 0.9324987 1.528561
RE               1.42088 0.8514976 1.990262
RE (HaKn)        1.42088 0.7971222 2.044637

meta documentation built on Sept. 14, 2021, 5:14 p.m.