RVS_btrap: use RVS to test associaton by bootrtrap, given phenotype (Y),...

In Struglab/RVS: Robust Variance Score (RVS) test for association of variants from next generation sequence data with binary traits using external controls

Description

use RVS to test associaton by bootrtrap, given phenotype (Y), expected values of genotypes for case and controls (X) estimated genotype frequency (P) and number of times of bootstrap (nboot)

Usage

RVS_btrap(Y, X, P, nboot, RVS = "TRUE")

Arguments

Y	- a vector with the phenotype for n individuals (=ncase+ncont), first ncase (y=1) then ncont (y=0) (integar)
X	- a vector of genotype for a snp, first ncase and then ncont
P	(vector with length 3 (double)) - estimated genotype frequency for a variant P(G=0), P(G=1) and P(G=2)
nboot	- number of bootstrap
RVS,	logic variable to indicate the estimation of variance of the score statistic.

Value

p-values for the snp

Struglab/RVS documentation built on May 9, 2019, 3:11 p.m.