pathPlot.compare: To compare differentially activated pathways and the involved...

In yingyonghui/CommPath:

To compare differentially activated pathways and the involved receptors between the selected clusters of two CommPath object

Description

To compare differentially activated pathways and the involved receptors between the selected clusters of two CommPath object

Usage

pathPlot.compare(
  object.1,
  object.2,
  select.ident,
  up.ident = NULL,
  diff.path.dat = NULL,
  top.n.path = 5,
  path.order = "P.val.adj",
  select.path = "all",
  p.thre = 0.05,
  top.n.receptor = 10,
  dot.ident.col = NULL,
  dot.ident.size = 1,
  dot.gene.col = NULL,
  dot.gene.size = 1,
  bar.pathway.col = NULL,
  label.text.size = 1,
  label.title.size = 1
)

Arguments

object.1	CommPath object 1
object.2	CommPath object 2 for comparison
select.ident	Plot the activated pathways for which cluster or cell type?
up.ident	Upstream clusters in the communication chain; default is all clusters
diff.path.dat	Data frame of defferential activation test result from comparePath; if NULL, comparePath would be run to get diff.path.dat
top.n.path	Top n pathways with the smallest adjusted p values to plot
path.order	Sort criteria used to select the top n pathways, either 'P.val' or 'P.val.adj', which represent the original and adjusted p values, or 'diff' which represents the mean (in t test) or median (in wilcox test) difference
select.path	Vector of pathways for which users want to present a chain plot; default is all, which means to plot all pathways. The parameter top.n.path would be masked if this one is set with specific pathways.
p.thre	Threshold for adjust p values; Only pathways with a adjust p valua < p.thre would be considered
top.n.receptor	Top n receptor with the largest log2FCs to plot
dot.ident.col	Color of the dots representing clusters
dot.ident.size	Size of the dots representing clusters
dot.gene.col	Color of the dots representing receptors
dot.gene.size	Size of the dots representing receptors
bar.pathway.col	Color of the bars reprsenting pathways
label.text.size	Text size in the plot
label.title.size	Text size of the title annotation of the plot

Value

Network plot showing the significantly differentially activated pathways between the selected clusters of two CommPath object, receptors involved in the pathways, and the upstream clusters which show LR connections with the selected cluster

yingyonghui/CommPath documentation built on June 15, 2025, 6:29 a.m.