SynergyFinder: Calculate and Visualize Synergy Scores for Drug Combinations

Build Status


Efficient implementations for all the popular synergy scoring models for drug combinations, including HSA, Loewe, Bliss and ZIP and visualization of the synergy scores as either a two-dimensional or a three-dimensional interaction surface over the dose matrix.


If you have any problems in using SynergyFinder, please contact Shuyu Zheng ( or Jing Tang (

Copyright & License

Code released under the Mozilla Public License 2.0.


In case you use the package in your work, we do appreciate a citation to our publication:

He L, Kulesskiy E, Saarela J, Turunen L, Wennerberg K, Aittokallio T, et al. (2018) Methods for High-throughput Drug Combination Screening and Synergy Scoring. In: von Stechow L, editor. Cancer Systems Biology: Methods and Protocols. New York, NY: Springer New York. P351-98.

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synergyfinder documentation built on April 4, 2021, 6 p.m.