dot-SolveLoewe: Solve the Loewe Additive Effect for Concentration...

In synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

Solve the Loewe Additive Effect for Concentration Combinations Isobologram

Usage

.SolveLoewe(concs, drug_par, drug_type, nsteps = 100)

Arguments

concs	A numeric vector. It contains the concentrations of tested drugs.
drug_par	A numeric vector. The parameters in fitted dose response curve.
drug_type	The type of model used to fit dose response curve.
nsteps	The total steps to calculate concentration combinations approaching to the true Loewe effect.

Value

A list contains 3 items:

• y_loewe the predicted Loewe additive effect which closes to .

• x_select the expected concentrations for each drug to achieve y_loewe.

• distance the smallest distance

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

synergyfinder documentation built on April 4, 2021, 6 p.m.