ImputeIC50: Impute Missing Value at IC50 Concentration of Drug
In synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description Usage Arguments Details Value Author(s)

View source: R/calculate_sensitivity_score.R

ImputeIC50 uses the particular experiment's values to predict the missing values at the desired IC50 concentration of the drug. This function is only called when trying to fix a drug at its selected IC50 concentration where the response values have not been tested in experiment.

1	ImputeIC50(response.mat, col.ic50, row.ic50)

`response.mat`	A matrix. It contains response value of a block of drug combination.
`col.ic50`	A numeric value. The IC50 value of drug added to columns.
`row.ic50`	A numeric value. The IC50 value of drug added to rows.

ImputeIC50 fits dose-response models (with drm function) by fixing the concentrations of the other drug successively, and uses each fit to predict the missing value at the combination (missing IC50, fixed conc).

A data frame contains all response value at the IC50 concentration of certein drug. It could be directly passed to function CalculateSens for scoring.