CalculateCSS: Calculate Combination Sensitivity Score

In synergyfinder: Calculate and Visualize Synergy Scores for Drug Combinations

Description

This function will calculate the Combination Sensitivity Score (CSS) for a drug combination block.

Usage

CalculateCSS(response, ic50)

Arguments

response	A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.
ic50	A list. It contains the relative IC50 for all the drugs in the combination.

Value

A data frame. It contains the CSS for each drug will one of the other drugs is at its IC50 and summarized CSS for the whole block.

Author(s)

• Shuyu Zheng [e-mail]

• Jing Tang [e-mail]

synergyfinder documentation built on April 4, 2021, 6 p.m.